E-ISSN: 2791-8823
Regression of Hypermetabolic Splenic Granulomata Mimicking Metastases Following Non-targeted Effect of Radiotherapy for Uterine Cervical Carcinoma [Cam Sakura Med J]
Cam Sakura Med J. 2021; 1(1): 37-42 | DOI: 10.4274/csmedj.galenos.2021.2021-8-6

Regression of Hypermetabolic Splenic Granulomata Mimicking Metastases Following Non-targeted Effect of Radiotherapy for Uterine Cervical Carcinoma

Nazmiye Deniz Arslan1, Sedef Da1, Aye Kutluhan Doan1, Nesrin Gray2, Hseyin zkurt3, Burak Ylmaz4
1University of Health Sciences Turkey, Yedikule Chest Disease and Toracic Surgery Training and Research Hospital, Clinic of Radiation Oncology, stanbul, Turkey
2University of Health Sciences Turkey, Atatrk Chest Disease and Toracic Surgery Training and Research Hospital, Clinic of Pathology, Ankara, Turkey
3University of Health Sciences Turkey, stanbul isli Hamidiye Etfal Training and Research Hospital, Clinic of Radiology, stanbul, Turkey
4University of Health Sciences Turkey, Baakehir am and Sakura City Hospital, Clinic of Nuclear Medicine, stanbul, Turkey

Objective: This study aimed to compare the effectiveness and to plan parameters of the Monte Carlo (MC)-based volumetric arc radiation therapy (VMAT) plan, which was devised using the equivalent uniform dose concept for endometrial cancers, to the dose volume (DV)-based helical tomotherapy (HT) plan. Additionally, both approaches were evaluated in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP). Material and Methods: The study comprised ten patients diagnosed with endometrial cancer, and treated with radixact tomotherapy unit. The target volumes (PTV) and organs at risks (OARs) were contoured through an accuracy planning system. All plans were devised to receive a total of 50.4 Gy in 28 fractions with the fractional dose to be 1.8 Gy for patient treatment. Monaco 5.51 planning system hosted all planning computed tomography images to devise MC-based VMAT plans. Both plans were analyzed in terms of TCP and NTCP. Results: DV-HT plans (CI: 1.1) came with the more conformal plan while the difference between both approaches was <1% for HI. Based on the results of the analyses, no statistical difference between DV-HT plan of MC-VMAT for the dose values of 2%, 30%, and 40% of rectal volume (p>0.05) was observed. The same results were obtained for the dose values of 2% and 30% of the bladder volume (p>0.05). The D5% of the femoral heads were 7 Gy which is < MC-VMAT plan compared to DV-HT plan. The NTCP values of all OARs were <1% in both approaches. Conclusion: Statistically, similar results were obtained in MC-VMAT and DV-HT plans for OARs doses when the treatment dose was given to PTV. Both approaches had no significant difference for NTCP statistically; however, the possibility of bone marrow complications to be investigated as well was concluded, so as to evaluate hematological toxicity.

Keywords: Cervical cancer, MRI, FDG-PET/CT, false positive, non-targeted effect

Nazmiye Deniz Arslan, Sedef Da, Aye Kutluhan Doan, Nesrin Gray, Hseyin zkurt, Burak Ylmaz. Regression of Hypermetabolic Splenic Granulomata Mimicking Metastases Following Non-targeted Effect of Radiotherapy for Uterine Cervical Carcinoma. Cam Sakura Med J. 2021; 1(1): 37-42

Corresponding Author: Nazmiye Deniz Arslan, Trkiye
Manuscript Language: English
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