E-ISSN: 2791-8823
Comparison of Colposcopic Biopsy Results of Non-HPV 16/18 Oncogenic Type Positive Patients [Cam Sakura Med J]
Cam Sakura Med J. 2021; 1(2): 64-68 | DOI: 10.4274/csmedj.galenos.2021.2021-8-13

Comparison of Colposcopic Biopsy Results of Non-HPV 16/18 Oncogenic Type Positive Patients

Nazl Aylin Vural1, Gizem Nur Kyan2, Ozan Karadeniz3, enay Erdoan Durmu4, zge Kocaman4, Hasan Turan1
1University of Health Sciences Turkey, Baakehir am and Sakura City Hospital, Clinic of Gynecology and Gynecologic Oncology, stanbul, Turkey
2University of Health Sciences Turkey, Baakehir am and Sakura City Hospital, Clinic of Obstetrics and Gynecology, stanbul, Turkey
3University of Health Sciences Turkey, Kanuni Sultan Sleyman Training and Research Hospital, Clinic of Obstetrics and Gynecology, stanbul, Turkey
4University of Health Sciences Turkey, Baakehir am and Sakura City Hospital, Clinic of Pathology, stanbul, Turkey

Objective: This study aimed to evaluate and compare the risk in detecting cervical intraepithelial neoplasia (CIN) 2+ or higher lesions by performing immediate colposcopy in patients with positive high-risk non-human papillomavirus (HPV) 16/18 subtypes, regardless of their cytology results.
Material and Methods: A total of 264 patients with HPV-positive subtypes, aged 20-65 years, with any type of cervical cytology results were included in the study. A liquid-based cytologic cervical cancer screening with HPV testing was carried out between November 2020 and May 2021. Cytological specimens were classified according to the Bethesda system (2014), and HPV identification was analyzed with Cobas 4800 system. Colposcopy-guided endocervical curettage and endometrial biopsy were performed.
Results: A total of 123 patients had HPV non-16/18 oncogenic types, wherein 34 (69.3%) had no dysplasia, 9 (18.3%) had CIN 1, and 2 (4.08%) had CIN 2-3.
Conclusion: Colposcopic evaluation may be considered in cases of non-16/18 high-risk HPV subtypes with abnormal cytologic results. Among the patients who had negative cervical cytology and positive non-HPV-16/18, 4.08% were women with CIN 2-3. Following the algorithm according to the guidelines, there will be a risk of 4.08% of misdiagnosing CIN 2+ lesions by gynecologists. Organizing large-scale randomized controlled studies will help in understanding the meaning or importance of this topic.

Keywords: Colposcopy, cytology, genotyping, human papillomavirus subtypes

Nazl Aylin Vural, Gizem Nur Kyan, Ozan Karadeniz, enay Erdoan Durmu, zge Kocaman, Hasan Turan. Comparison of Colposcopic Biopsy Results of Non-HPV 16/18 Oncogenic Type Positive Patients. Cam Sakura Med J. 2021; 1(2): 64-68

Corresponding Author: Nazl Aylin Vural, Trkiye
Manuscript Language: English
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