Cam Sakura Med J. 2023; 3(3): 116-119 | DOI: 10.4274/csmedj.galenos.2023.2023-5-2

Active Pulmonary Tuberculosis During Interferon Beta-1a Therapy in a Child with Multiple Sclerosis: A Case Report

Pakize Cennetoðlu¹, Zeynep Öz¹, Canan Caymaz², Peren Perk Yücel¹, Pýnar Arýcan¹, Ýhsan Kafadar^1
1University of Health Sciences Turkey, Baþakþehir Çam and Sakura City Hospital, Clinic of Pediatrics, Division of Pediatric Neurology, Ýstanbul, Turkey
²University of Health Sciences Turkey, Baþakþehir Çam and Sakura City Hospital, Clinic of Pediactrics, Division of Pediatric Infectious Diseases, Ýstanbul, Turkey

Interferon (IFN) beta (β) is a potent anti-inflammatory and immunomodulatory agent that is used for treating patients with multiple sclerosis (MS). In this study, we present the case of a 15-year-old female patient diagnosed with MS and treated with IFN β-1a for six months who was referred to the emergency department with complaints of fatigue, fever, and coughing. She was diagnosed with pulmonary tuberculosis (TB). IFN β-1a therapy was stopped and anti-TB treatment was initiated. After nine months of therapy, she recovered from TB. This case presented with a rare side effect during the treatment of pediatric-onset MS with immunomodulatory drugs, demonstrating the importance of screening and close follow-up of patients with TB.

Keywords: Case report, interferon beta, multiple sclerosis, pediatric neurology, tuberculosis

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